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Search Results for " colon carcinoma "

ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T2676	PF-04217903		c-Met/HGFR
	MET Tyrosine Kinase Inhibitor PF-04217903 is an orally bioavailabe, small-molecule tyrosine kinase inhibitor with potential antineoplastic activity.		c-Met/HGFR
T6609	NMS-E973		HSP
	NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.		HSP
T28410	PHPS1	PHPS-1,PHPS 1	Phosphatase
	PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.		Phosphatase
T2455	PFK-015	PFK15,PFK 015	Glucokinase , Autophagy
	PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).		Glucokinase , Autophagy
T19147	5-ALA benzyl ester hydrochloride	Benzyl-ALA hydrochloride	Others , Endogenous Metabolite
	5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) is a protoporphyrin precursor. 5-ALA benzyl ester hydrochloride is used as a photodetection agent. 5-ALA benzyl ester hydrochloride could induce protoporphyrin ...		Others , Endogenous Metabolite
TQ0157	EIPA	L593754,MH 12-43	Sodium Channel , TRP/TRPV Channel
	EIPA (L593754) (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.		Sodium Channel , TRP/TRPV Channel
T1520	Aliskiren hemifumarate	CGP 60536,SPP 100,CGP60536B	RAAS , Autophagy
	Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.		RAAS , Autophagy
T16034	Meclinertant	SR 48692	Others
	Meclinertant is an effective, selective, nonpeptide, and orally active neurotensin receptor 1 (NTS1) antagonist. Meclinertant competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization (pA2 : 8.13), in...		Others
T5618	AK-1		Sirtuin
	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.		Sirtuin
T77651	Tubulin polymerization-IN-47		Microtubule Associated
	Tubulin polymerization-IN-47 is a tubulin polymerization inhibitor and mitotic inhibitor with antitumor activity and inhibitory effects on neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 an...		Microtubule Associated
T71912	PD 173955-Analog1
	PD 173955-Analog1 is a potent c-Src inhibitor known to have activity against a variety of cancers including colon, lung, head and neck carcinoma.
T20050	Cinnamamide	NSC 32953
	Cinnamamide is an amide of trans-cinnamic acid and a metabolite of Streptomyces. It also reduced tumor weight in a mouse model of C26 murine colon carcinoma, in vivo.
T72740	N-Octyl caffeate
	n-Octyl caffeate demonstrates anti-cancer and apoptosis-inducing properties in highly liver-metastatic murine colon 26-L5 carcinoma cell lines.
T71890	F5446
	F5446 is a SUV39H1 inhibitor. F5446 has an EC50 of 0.496 μmol/L for SUV39H1 enzymatic activity. H3K9me3 was enriched in the promoters of GZMB, PRF1, FASLG, and IFNG in quiescent T cells. F5446 inhibited H3K9me3, thereby ...
T72927	IMD-catechol		NF-κB
	IMD-catechol is an innovative dimer compound combining an imidazoquinolinone structure with NF-κB immunomodulatory activity, which enhances treatment outcomes in a CT26 mouse colon carcinoma model and demonstrates low ad...		NF-κB
T60933	B-Raf IN 7
	B-Raf IN 7 (compound 6a) is a potent inhibitor of B-Raf with an IC 50 of 110.23 nM. B-Raf IN 7 has antitumor activity against colon carcinoma cells(HCT-116), mammary gland cells(MCF-7), hepatocellular carcinoma cells(HEP...
T60727	B-Raf IN 8
	B-Raf IN 8 (compound 7g) is a potent inhibitor of B-Raf (IC 50 = 70.65 nM). B-Raf IN 8 shows antitumor activity which has IC 50 values of 9.78, 13.78, 18.52 and 29.85 μM against hepatocellular carcinoma (HEPG-2), colon ...
T69618	XR3054
	XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12....
T36426	Eicosapentaenoyl 1-propanol-2-amide
	Monoacylglycerols (MAGs) of ω-3 polyunsaturated fatty acids have diverse physiological and health effects. In particular, MAGs containing docosahexaenoic acid or eicosapentaenoic acid have anti-proliferative properties a...
TMIH-0521	Silibinin-d3
	Silibinin-d3 is a deuterated compound of Silibinin. Silibinin has a CAS number of 22888-70-6. Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture...
T36627	Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)
	Lysine-specific demethylase inhibitor (1C) (LSD inhibitor (1C)) is an inhibitor of LSD1, a repressive demethylase selective for histone H3 lysine 4 (H3K4).1,2LSD inhibitor (1C) inhibits LSD1 activity by 85.9% when used a...
T36452	1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)
	1-Arachidonoyl lysophosphatidic acid is a phospholipid containing arachidonic acid at the sn-1 position. It has been found in rat brain as 37% of the arachidonic acid-containing lysophosphatidic acid (LPA) species and is...
T36846	Chromomycin A2
	Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It als...
T71293	Nifuroxazide-d4
	Nifuroxazide-d4 is intended for use as an internal standard for the quantification of nifuroxazide by GC- or LC-MS. Nifuroxazide is a nitrofuran antibiotic. It is active against strains of the enteropathogenic bacteria C...

Compounds

Synonym: PHPS-1,PHPS 1

Target: Phosphatase

PFK-015

T2455

Synonym: PFK15,PFK 015

Target: Glucokinase, Autophagy

5-ALA benzyl ester hydrochloride

T19147

Synonym: Benzyl-ALA hydrochloride

Target: Others, Endogenous Metabolite

EIPA

TQ0157

Synonym: L593754,MH 12-43

Target: Sodium Channel, TRP/TRPV Channel

Aliskiren hemifumarate

T1520

Synonym: CGP 60536,SPP 100,CGP60536B

Target: RAAS, Autophagy

Tubulin polymerization-IN-47

T77651

Synonym:

Target: Microtubule Associated

Eicosapentaenoyl 1-propanol-2-amide

Lysine-specific Demethylase Inhibitor (1C) (hydrochloride)

T36627

Synonym:

Target:

1-Arachidonoyl Lysophosphatidic Acid (ammonium salt)

カタログ番号	製品名	別名	ターゲット
T5S1133	Ganoderic acid D		Apoptosis , Sirtuin
	1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 micr...		Apoptosis , Sirtuin
T1709	2'-Deoxyinosine	Guanine deoxyriboside,Deoxyinosine	Others , Endogenous Metabolite
	2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency.		Others , Endogenous Metabolite
T5746	Dictamine	Dictamnine,Dectamine	Apoptosis , Anti-infection , Antibacterial , Antifungal
	Dictamine (Dectamine) shows anticholinesterase, anti-inflammatory, mutagenic, and has antimicrobial activity against bacteria and fungi. It has the ability to exert cytotoxicity in human cervix, colon, and oral carcinoma...		Apoptosis , Anti-infection , Antibacterial , Antifungal
T5S0506	Rotundic acid	Rutundic acid	Apoptosis , Others , p38 MAPK , Akt , mTOR
	Rotundic acid (Rutundic acid), a natural compound, exhibit cytotoxic activities toward human hepatocellular carcinoma (HepG2), malignant melanoma (A375), SCLC (NCI-H446), breast cancer (MCF-7), and colon cancer (HT-29) c...		Apoptosis , Others , p38 MAPK , Akt , mTOR
TN1405	Arnicolide D		Akt , Caspase , PI3K , STAT , mTOR
	Arnicolide D is a sesquiterpene lactone. Arnicolide D isolates from Centipeda minima. Arnicolide D modulates the cell cycle, activates the caspase signaling pathway and inhibits the PI3K/AKT/mTOR and STAT3 signaling path...		Akt , Caspase , PI3K , STAT , mTOR
T1660	Silibinin	Silibinin A,Silybin,Silymarin I	Reactive Oxygen Species , Autophagy
	Silibinin (Silybin) is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin an...		Reactive Oxygen Species , Autophagy
TN2029	P-Hydroxy-5,6-dehydrokawain	4'-Hydroxydehydrokawain	Others
	p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain.		Others
T40708	Neoanhydropodophyllol
	Neoanhydropodophyllol, a cyclolignan derivative, exhibits potent antineoplastic activity by exerting cytotoxic effects on various cancer cell lines including leukemia, lung carcinoma, and colon carcinoma.
TN3495	Benzyl ferulate		TNF , Antifection
	Benzyl ferulate has antimicrobial activity. It also shows good anti-proliferative against three gastro-intestinal cancer cell lines(HCT-116 colon carcinoma, KYSE-30 oesophageal squamous cancer, and NCI-N87 gastric carcin...		TNF , Antifection
TN5093	Taiwanhomoflavone A		COX
	Taiwanhomoflavone A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.		COX
TN2813	23-deoxojessic acid		Others
	23-Deoxojessic acid possesses strong cytotoxicity towards highly liver metastatic murine colon 26-L5 carcinoma cells, with ED50 values equal to or less than 6 microM.		Others
T73063	Rostratin B
	Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.
TN1645	Flavokawain C		NADPH-oxidase , MAPK , AChR
	Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle and promoted apoptosis, associated with endoplasmic reticu...		NADPH-oxidase , MAPK , AChR
T73064	Rostratin C
	Rostratin C, a cytotoxic disulfide, exhibits in vitro cytotoxicity against human colon carcinoma (HCT-116), demonstrating an IC50 value of 0.76 μg/mL.
TN3660	Cinnamyl caffeate		Calcium Channel
	Cinnamyl caffeate has cardiovascular protective effects, it can increase H9c2 cellular antioxidant potential, decrease intracellular calcium ion ([Ca2+]i) level, and prevent cell apoptosis; it possesses potent antiprolif...		Calcium Channel
TN4623	Nagilactone C		Antifection
	Nagilactone C and phyllanthoside are novel protein synthesis inhibitors, they are specific for the eukaryotic translation apparatus, function in vivo and in vitro, and interfere with translation elongation. Nagilactone C...		Antifection
T73062	Rostratin A
	Rostratin A, a cytotoxic disulfide isolated from the marine-derived fungus Exserohilum rostratum, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an inhibitory concentration 50 (IC ...
TMA1008	Ganoderic acid S		Others
	A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the t...		Others
TN3152	6-Acetonyldihydrochelerythrine		ERK , BCL , Akt , HIV Protease , PPAR , p53
	6-Acetonyldihydrochelerythrine exhibits significant antioxidant activities, it exhibits significant anti-HIV activity in H9 lymphocytes with EC50 and TI (Therapeutic Index) values of 1.77 microg/mL and 14.6, respectively...		ERK , BCL , Akt , HIV Protease , PPAR , p53
TN3404	Altholactone		BCL , p38 MAPK , ROS , Akt , Caspase , Antifection , p53
	Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of various types of cancer cells through inducing apoptosis vi...		BCL , p38 MAPK , ROS , Akt , Caspase , Antifection , p53
TN3870	Iriflophenone 2-O-Rhamnoside	Dimethylmatairesinol	Others
	Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against t...		Others

天然物製品

Ganoderic acid D

T5S1133

Synonym:

Target: Apoptosis, Sirtuin

2'-Deoxyinosine

T1709

Synonym: Guanine deoxyriboside,Deoxyinosine

Target: Others, Endogenous Metabolite

Dictamine

T5746

Synonym: Dictamnine,Dectamine

Target: Apoptosis, Anti-infection, Antibacterial, Antifungal

Rotundic acid

T5S0506

Synonym: Rutundic acid

Target: Apoptosis, Others, p38 MAPK, Akt, mTOR

Arnicolide D

TN1405

Synonym:

Target: Akt, Caspase, PI3K, STAT, mTOR

Silibinin

T1660

Synonym: Silibinin A,Silybin,Silymarin I

Target: Reactive Oxygen Species, Autophagy

p-Hydroxy-5,6-dehydrokawain

TN2029

Synonym: 4'-Hydroxydehydrokawain

Target: Others

Neoanhydropodophyllol

Target: TNF, Antifection

Target: NADPH-oxidase, MAPK, AChR

Target: Calcium Channel

6-Acetonyldihydrochelerythrine

TN3152

Synonym:

Target: ERK, BCL, Akt, HIV Protease, PPAR, p53

Altholactone

TN3404

Synonym:

Target: BCL, p38 MAPK, ROS, Akt, Caspase, Antifection, p53

Iriflophenone 2-O-Rhamnoside

TN3870

Synonym: Dimethylmatairesinol

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01344	MAP1D Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	Methionine aminopeptidase 1D, also known as MAP1D, is a member of the peptidase M24A family. N-terminal methionine removal is an important cellular process required for proper biological activity, subcellular localizatio...
TMPJ-00947	RPS19 Protein, Human, Recombinant	Human	E. coli
	40S Ribosomal Protein S19 (RPS19) is a ribosomal protein that Belongs to the ribosomal protein S19e family. RPS19 is located in the nucleoli, and higher level expression is seen in colon carcinoma tissue than normal colo...
TMPY-03521	DcR3 Protein, Human, Recombinant (hFc)	Human	Baculovirus Insect Cells
	Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor ...
TMPJ-00859	AREG Protein, Human, Recombinant	Human	E. coli
	Amphiregulin (AREG) is a single-pass membrane protein with 252 amino acids. AREG belongs to the amphiregulin family, which contains 1 EGF-like domain. AREG is expressed in a variety of tissues including ovary, placenta, ...
TMPY-04930	Notch 2 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPJ-00055	Podoplanin Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Podoplanin belongs to the podoplanin family, also known as Glycoprotein 38. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmem...
TMPY-02176	Harmonin/USH1C Protein, Human, Recombinant (His)	Human	E. coli
	Harmonin, also known as Antigen NY-CO-38 / NY-CO-37, Autoimmune enteropathy-related antigen AIE-75, Protein PDZ-73, Renal carcinoma antigen NY-REN-3, Usher syndrome type-1C protein and USH1C, is a protein that is express...